COPDGene Study Collaborations

COPDGene is a multi-site, longitudinal, NIH-funded research study that started in 2007 to investigate genetic factors that underlie risk for COPD among smokers and to understand heterogeneity in the clinical presentation of COPD (James Crapo, MD and Ed Silverman, MD, PhD are the Co-Principal Investigators of the study).  COPDGene initially enrolled 10,000 current and former smokers at 21 sites across the United States, including the University of Iowa (Dr. Alejandro Comellas is the COPDGene clinical site PI for UIowa, and is a Co-Investigator on Dr. Hoth’s COPD and the Brain study). 

Dr. Hoth is overseeing the addition of a cognitive screening measure (the MINI-Cog) to the Phase 3 visit of COPDGene, which is administered at all study sites. Dr. Hoth also leads the Social and Behavioral Sciences Committee for COPDGene, a group of approximately 20 investigators focused on analyzing behavioral data (e.g., symptoms of depression and anxiety) from the Phase 2 and 3 waves of COPDGene data collection. 

This work is funded by a subcontract to the University of Iowa from NIH/NHLBI, U01 HL089897, Genetic Epidemiology of COPD (UIowa Site PI: Eric Hoffman, PhD).


Curcumin Supplementation in Chronic Kidney Disease

Dr. Diana Jalal is a nephrologist at the University of Iowa, and the Principal Investigator of the NHLBI funded Curcumin study, which examines the impact of curcumin supplementation in improving vascular and cognitive function for adults with chronic kidney disease. Dr. Hoth is a Co-Investigator involved in training and interpretation of the NIH Toolbox Cognition Battery that is completed as part of study procedures. 

This research study is funded by NIH/NHLBI R01 HL134738 (Jalal, PI).


Sleep Heart Aging Study

Dr. Chooza Moon, an Assistant Professor in Nursing, is the Principle Investigator of the Sleep Heart Aging Study, which seeks to understand the association between altered patterns of sleep and white matter changes in the brain, in patients with coronary artery disease.  Dr. Hoth is a collaborator and mentor who oversees the administration of cognitive assessment measures, and is involved with project development and interpretation of data with other members of Dr. Moon’s research team. 

Dr. Moon’s research is funded by the University of Iowa Center on Aging and the Aging Mind and Brain Initiative.


Cognitive Difficulties in Sarcoidosis

In 2018, the University of Iowa was established as a new member of the Foundation for Sarcoidosis Research Clinical Studies Network with a project led by pulmonologist Dr. Nabeel Hamzeh. Dr. Hoth is a Co-Investigator on the research focused on evaluating cognitive concerns among patients with sarcoidosis.